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目的观察辛伐他汀(商品名:舒降之)对糖尿病合并高脂血症的疗效。方法80例病人(男性42例,女性38例,平均年龄62.6岁(33～84岁)辛伐他汀每晚10mg顿服。结果经过4周的治疗,血总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)分别由7.24±0.61、3.43±1.46、5.05±0.14mmol/L下降到5.90±1.02、2.94±1.96、3.86±0.24mmol/L,差异有统计学意义(P<0.05),高密度脂蛋白(HDL-C)由0.84±0.16mmol/L上升到1.05±0.21mmol/L,差异有统计学意义(P<0.05)。结论辛伐他汀治疗糖尿病合并高脂血症病人32安全有效,无明显不良反应。
Objective To observe the effect of simvastatin (trade name: Shujiangzhi) on diabetic hyperlipidemia. Methods Eighty patients (42 males and 38 females, mean age 62.6 years (33-84 years old) simvastatin 10 mg daily.Results After 4 weeks of treatment, total cholesterol (TC), triglyceride TG and LDL-C decreased from 7.24 ± 0.61, 3.43 ± 1.46 and 5.05 ± 0.14 mmol / L to 5.90 ± 1.02, 2.94 ± 1.96 and 3.86 ± 0.24 mmol / L, respectively, with statistical significance (P <0.05), HDL-C increased from 0.84 ± 0.16mmol / L to 1.05 ± 0.21mmol / L, the difference was statistically significant (P0.05) .Conclusion Simvastatin treatment of diabetes mellitus with high Lipid patients 32 safe and effective, no significant adverse reactions.