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应用免疫组织化学和自动图像分析(AIAI)技术对128例老年人慢性萎缩性胃炎(CAG)、不典型增生(ATP)、胃癌(GC)及正常胃粘膜进行肿瘤标记物(MG_7)和细胞核DNA含量及形态参数定量测定。结果表明,MG_7的阳性表达率在GC组为88.0％,ATP组8.7％,CAG组3.3％,随病变程度加重,细胞核DNA含量及形态参数均明显增高,DNA含量与MG_7染色程度存在正相关。提示细胞DNA含量、形态参数及MG_7可作为胃癌早期诊断及癌前病变监测的有用指标。
Immunohistochemical and automated image analysis (AIAI) techniques were used to detect tumor markers (MG_7) and nuclear DNA in 128 elderly patients with chronic atrophic gastritis (CAG), atypical hyperplasia (ATP), gastric cancer (GC), and normal gastric mucosa. Quantitative determination of content and morphological parameters. The results showed that the positive expression rate of MG_7 was 88.0% in the GC group, 8.7% in the ATP group and 3.3% in the CAG group. With the severity of the lesions, the nuclear DNA content and morphological parameters were significantly increased, and the DNA content was positively correlated with the degree of MG_7 staining. It is suggested that cell DNA content, morphological parameters and MG_7 can be useful indicators for early diagnosis of gastric cancer and monitoring of precancerous lesions.