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我们对9名生活在海拔3700米处的高原红细胞增多症男性患者转移到海拔2260米处一周后,测定在50W功率下运动5分钟前后的肺动脉压力变化及运动后恢复时间,并在给予0.1mg/kg纳酪酮后重复上述测定,结果显示,运动可使肺动脉压明显升高,而纳酪酮可降低受试者在运动前及运动导致的肺动脉压急剧升高,并能使运动后肺动脉压及心率恢复到运动前水平所需时间减少,以上结果提示高原性红细胞增多症患者所表现的肺动脉压升高,可能部分是由于患者血浆内啡肽升高和/或肺血管对内啡肽的敏感性升高所致。
We transferred nine male PLT patients who lived at an altitude of 3700 meters to an altitude of 2260 meters for one week and measured changes in pulmonary artery pressure before and after exercise at a power of 50 W for 5 minutes and post-exercise recovery time. After administration of 0.1 mg / kg ketolyse after repeated measurements, the results show that exercise can significantly increase pulmonary artery pressure, while natto ketone can reduce the subjects before exercise and exercise-induced pulmonary hypertension increased sharply, and can make the pulmonary artery after exercise Pressure and heart rate to return to pre-exercise levels to reduce the time required, the above results suggest that patients with altitude-induced polycythemia showed elevated pulmonary arterial pressure, may be due in part to increased plasma endorphin and / or pulmonary vascular endorphin Due to the increased sensitivity.