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人类疱疹病毒8型(HHV-8)又称卡波西肉瘤疱疹病毒(KSHV),发现于HIV的卡波西肉瘤患者,该病毒的潜伏性和裂解性是感染后引起卡波西肉瘤的重要特性,通过DNA,RNA及蛋白表达等分子生物学研究,HHV-8的阳性率达70%以上。随后对HHV-8的某些基因亚型的研究发现,A-Z六种亚型及24个以上分支,这些亚型与卡波西肉瘤的侵袭性有着重要联系。非卡波西肉瘤中,HHV-8通过抑制抑癌基因表达、激活癌基因、干扰细胞生长分化相关信号等机制影响细胞生长周期调控等功能,诱导细胞恶性转化。
Human herpes virus type 8 (HHV-8), also known as Kaposi’s Sarcoma herpesvirus (KSHV), is found in patients with Kaposi’s sarcoma of HIV and its latent and lytic properties are important for causing Kaposi’s sarcoma after infection Characteristics, through the molecular biology of DNA, RNA and protein expression, HHV-8 positive rate of more than 70%. Subsequent studies of certain gene subtypes of HHV-8 found that there are six subtypes of A-Z and more than 24 branches, and these subtypes are important for the aggressiveness of Kaposi’s sarcoma. In non-Kaposi’s sarcoma, HHV-8 induces cell malignant transformation by inhibiting tumor suppressor gene expression, activating oncogenes, interfering with signals related to cell growth and differentiation, and other mechanisms that affect cell cycle regulation.