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目的观察不稳定型心绞痛(UAP)患者窦性心率震荡(HRT)的变化及比索洛尔对HRT的影响。方法选择有室性早搏的UAP患者60例,及健康对照60例进行24 h动态心电图(DCG)检查,分别对震荡初始(TO)、震荡斜率(TS)进行分析,UAP组患者每日服用比索洛尔4周后复查DCG及TO、TS。结果UAP组与对照组比较,TO明显升高,TS明显降低;UAP患者恶性室性心律失常组与非恶性室性心律失常组对比,TO升高、TS下降;UAP患者服用比索洛尔前后对比,TO降低、TS增加,HRT明显改善。结论UAP组HRT明显异常,HRT异常可作为预测UAP恶性室性心律失常发生及判断预后的重要指标,比索洛尔能减少室性心律失常的发生率,改善HRT。
Objective To investigate the changes of sinus rhythm of heart rate (HRT) in patients with unstable angina pectoris (UAP) and the effect of bisoprolol on HRT. Methods 60 cases of UAP patients with premature ventricular contractions and 60 healthy controls were examined by 24-hour Holter electrocardiogram (DCG). The initial TO and the concussion slope (TS) were analyzed respectively. The patients in UAP group were treated daily Four weeks after the review of DCG and TO, TS. Results Compared with the control group, TO increased significantly and TS significantly decreased in UAP group. Compared with non-malignant ventricular arrhythmia group, TO increased and TS decreased in patients with UAP and before and after UAP patients taking bisoprolol , TO decreased, TS increased, HRT significantly improved. Conclusion The HRT of UAP group is obviously abnormal. HRT abnormality can be used as an important index to predict the occurrence of malignant ventricular arrhythmia and prognosis in UAP group. Bisoprolol can reduce the incidence of ventricular arrhythmia and improve HRT.