基膜是分布广泛的细胞外基质成分 ,含有层粘蛋白、纤维蛋白等多种成分 ,构成了机体细胞与组织间的屏障。细胞发生恶变时 ,由于基膜在结构、分布和数量上都发生变化 ,有利于肿瘤的浸润和转移。本文采用层粘蛋白和Ⅳ型胶原抗体检测鼻咽癌中基膜的表达 ,探讨基膜与癌细胞分化 ,癌 The basement membrane is a widely distributed component of the extracellular matrix that contains many components, such as laminin and fibrin, that form the barrier between cells and tissues in the body. Cell malignant transformation, due to changes in the structure, distribution and quantity of the basement membrane, is conducive to tumor invasion and metastasis. In this paper, laminin and type Ⅳ collagen antibody detection of nasopharyngeal carcinoma in the basement membrane expression, to explore the basement membrane and cancer cell differentiation, cancer