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目的:检测胎盘滋养细胞中胰岛素样生长因子-1(IGF-1)表达水平,评估IGF-1在妊娠期高血压疾病中的作用。方法:用免疫组化法测定胎盘组织中IGF-1的表达,检测正常妊娠胎盘滋养细胞60例、妊娠期高血压疾病患者胎盘滋养细胞126例中IGF-1的表达水平,并通过观察切片中滋养细胞免疫染色情况对结果进行判定。结果:与正常胎盘滋养细胞比较,妊娠期高血压疾病患者胎盘滋养细胞中IGF-1的表达强度显著降低。结论:胎盘滋养细胞表达IGF-1的多少,与妊娠期高血压疾病的发生有关。
Objective: To detect the expression of insulin-like growth factor-1 (IGF-1) in placental trophoblast and evaluate the role of IGF-1 in hypertensive disorders of pregnancy. Methods: The expression of IGF-1 in placenta was detected by immunohistochemical method. The expression of IGF-1 in placental trophoblast in 60 cases of normal pregnancy and 126 cases of gestational hypertensive disorder were detected. Trophoblast immunostaining to determine the outcome. Results: Compared with normal placental trophoblast cells, the expression of IGF-1 in placental trophoblast cells was significantly lower in patients with gestational hypertension. Conclusion: The number of IGF-1 expressed by placental trophoblast cells is related to the occurrence of hypertensive disorders during pregnancy.