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目的评价牙周病与冠心病的关联程度,为制定预防措施提供依据。方法检索符合本研究分析条件的牙周病与冠心病相关性文献,采用Meta分析法,进行定量综合分析。运用Rev Man 4.2分析软件和SPSS 13.0统计软件计算相关危险因素OR或RR值及95%CI,并绘制森林图。结果共筛选出相关文献13篇,其中10篇为病例-对照研究,合并OR值为2.21,95%CI为1.91～2.56,3篇为队列研究,合并RR值=1.40,95%CI为1.28～1.54。对所有研究进行异质性检验,各研究差别无统计学意义(χ2=9.08,P=0.70),采用固定效应模型进行Meta分析,表明有无牙周病对患冠心病的危险性差别有统计学意义(RR=1.43,95%CI为1.35～1.52)。结论牙周病与冠心病呈显著相关性,且可能互为致病和加重病情的危险因素。
Objective To evaluate the correlation between periodontal disease and coronary heart disease and to provide the basis for making preventive measures. Methods The literature about the relationship between periodontal disease and coronary heart disease, which accords with the analysis conditions of this study, was retrieved and analyzed by Meta analysis. Rev Man 4.2 analysis software and SPSS 13.0 statistical software were used to calculate the OR or RR of the relevant risk factors and 95% CI, and the forest map was drawn. Results A total of 13 articles were screened, of which 10 were case-control studies with a combined OR of 2.21 and 95% CI of 1.91-2.56. The cohort was cohort study with RR of 1.40 and 95% CI of 1.28 ~ 1.54. All studies were heterogeneity test, the difference was not statistically significant (χ2 = 9.08, P = 0.70), using the fixed effect model for meta-analysis, showing the presence or absence of periodontal disease risk of coronary heart disease with statistics Significance (RR = 1.43, 95% CI 1.35 ~ 1.52). Conclusion There is a significant correlation between periodontal disease and coronary heart disease, which may be the risk factors for the pathogenesis and aggravation of the disease.