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目的探讨低分子量肝素(LMWH)对大鼠重症急性胰腺炎(SAP)死亡率、血清超氧化物歧化酶(SOD)和丙二醛(MDA)的影响。方法本研究将54只Wistar大鼠随机分为假手术组、SAP模型组及SAP低分子量肝素治疗组,每组18只,比较术后3组大鼠死亡率及术后12,24,48和72 h血清SOD和MDA的变化。统计学处理采用SPSS 13.0软件,两组均数比较采用t检验,率的比较用χ2检验,P<0.05为差异有统计学意义。结果SAP低分子量肝素治疗组死亡率明显低于SAP模型组,差异有统计学意义(P<0.01);与对照组相比,SAP低分子量肝素治疗组血中SOD活性较高而MDA水平较低,差异有统计学意义(P<0.01,P<0.05)。结论本研究结果表明,LMWH可明显降低SAP大鼠死亡率,提高SOD活性,抑制MDA产生。
Objective To investigate the effects of low molecular weight heparin (LMWH) on mortality, serum superoxide dismutase (SOD) and malondialdehyde (MDA) in severe acute pancreatitis (SAP) rats. Methods In this study, 54 Wistar rats were randomly divided into sham operation group, SAP model group and SAP low molecular weight heparin treatment group, with 18 rats in each group. The mortality and postoperative 12, 24, 48 and Changes of serum SOD and MDA in 72 h. Statistical analysis using SPSS 13.0 software, the two groups were compared using t test, the rate was compared with the χ2 test, P <0.05 for the difference was statistically significant. Results The mortality of low molecular weight heparin treatment group was significantly lower than that of SAP model group (P <0.01). Compared with the control group, SAP low molecular weight heparin treatment group had higher SOD activity and lower MDA level , The difference was statistically significant (P <0.01, P <0.05). Conclusion The results of this study indicate that LMWH can significantly reduce the mortality of SAP rats, increase the activity of SOD and inhibit the production of MDA.