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目的探讨模拟失重对健康人肺功能的影响。方法选择12名健康男性青年作为研究对象,采用头低位-6°卧床96h模拟失重。对受试者在试验开始前即刻(坐位、平卧位),-6°卧位24、48、72、96h和试验结束即刻的脉搏(P),动脉血氧饱和度(SO2),肺容积指标[肺活量(VC)、补呼气量(ERV)、分钟通气量(MV)],肺通气功能[用力肺活量(FVC)、第一秒用力呼气量(FEV1)、最大呼气中期流速(MMEF)、25%肺活量最大呼气流速(V25)、50%肺活量最大呼气流速(V50)、用力吸气肺活量(FIVC)、用力吸气一秒量(FIV1)和最大通气量(MVV)]进行对比分析。结果从坐位变成平卧位、-6°卧位直至结束时,P与SO2均无明显变化。从坐位变成平卧位后,除MV以外的各项肺容积指标和肺通气功能指标均有明显降低,而从平卧位变为-6°卧位后,除FVC以外的各项肺容积和肺通气功能指标均有进一步降低。结论模拟失重后健康人体的肺容积和通气功能会有所降低。
Objective To investigate the effects of simulated weightlessness on lung function in healthy people. Methods Twelve healthy male youths were selected as study subjects, and the head-low -6 ° bed rest was used to simulate weightlessness. Immediately before the start of the trial (sitting, supine position), - 6 ° supine 24,48,72,96h and the end of the experiment immediately after the pulse (P), arterial oxygen saturation (SO2), lung volume (VVC, ERV, MV), pulmonary ventilatory function (FVC), forced expiratory volume one second (FEV1), maximum expiratory flow rate ( MMEF, V25, V25, V50, FIVC, FIV1, and MVV] For comparative analysis. Results from sitting position to supine position, -6 ° supine until the end, P and SO2 no significant change. From sitting position to supine position, the lung volume index and pulmonary ventilation index except MV were significantly reduced, and from supine position to -6 ° supine position, in addition to the FVC lung volume And pulmonary ventilation function indicators have been further reduced. Conclusions The lung volume and ventilation of healthy people will be reduced after simulated weightlessness.