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目的：研究高原肺水肿患者血浆ＮＯ含量与红细胞膜ＡＴＰａｓｅ的活性。方法：在海拔３ ７００ｍ 对收治的１１例高原肺水肿患者在治疗前和治愈后分别检测其血浆ＮＯ、乳酸、ＬＰＯ含量和红细胞Ｃａ２＋ － Ｍｇ２＋ － ＡＴＰａｓｅ、Ｎａ＋ － Ｋ＋ － ＡＴＰａｓｅ活性。结果：治疗前血浆ＮＯ含量、红细胞Ｃａ２＋ － Ｍｇ２＋ － ＡＴＰａｓｅ和Ｎａ＋ － Ｋ＋ － ＡＴＰａｓｅ活性非常显著低于治愈后水平（Ｐ＜ ０．００１ 和Ｐ＜ ０．０１），治疗前的血乳酸和ＬＰＯ水平非常显著地高于治愈后水平（Ｐ＜ ０．００１）。两种ＡＴＰａｓｅ活性与血浆ＮＯ呈高度正相关（Ｐ＜ ０．０１），与血乳酸和ＬＰＯ呈高度负相关（Ｐ＜ ０．０１）。结论：高原肺水肿与红细胞膜ＡＴＰａｓｅ活性、血浆ＮＯ含量改变和自由基损伤关系密切。
Objective: To study the plasma NO content and erythrocyte membrane ATPase activity in patients with high altitude pulmonary edema. Methods: The levels of NO, lactate and LPO and the activities of Ca2 + - Mg2 + - ATPase and Na + - K + - ATPase in erythrocytes of 11 patients with altitude pulmonary edema at 3 700 m altitude were measured before and after the treatment. Results: The levels of NO, the activities of Ca2 + - Mg2 + - ATPase and Na + - K + - ATPase in erythrocytes were significantly lower than those before treatment (P <0.001 and P <0.01), and the blood lactate and LPO Very significantly higher than the post-cure level (P <0.001). The two ATPase activities were positively correlated with plasma NO (P <0.01), but negatively correlated with LPO (P <0.01). Conclusion: There is a close relationship between altitude pulmonary edema and erythrocyte membrane ATPase activity, plasma NO content and free radical damage.