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目的探讨急性心肌梗死患者血清胆红素水平与冠状动脉病变严重程度的相关性。方法选取经冠状动脉造影确诊为急性心肌梗死的患者291例,测定患者血清总胆红素(TBIL)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)及甘油三酯(TG)水平。以冠脉病变支数、冠脉狭窄程度及冠脉病变积分来评价冠状动脉病变的严重程度。结果急性心肌梗死单支病变患者血清TBIL明显高于双支病变(p=0.042)和三支病变(p=0.013)患者,血清TBIL水平与冠脉病变支数呈负相关(p=0.039)。而急性心肌梗死双支病变与三支病变相比血清TBIL水平无显著降低(p=0.746)。血清TBIL水平与冠状动脉评分无显著相关性。结论血清胆红素水平在一定程度上可能与急性心肌梗死单支病变相关。
Objective To investigate the correlation between the level of serum bilirubin and the severity of coronary artery disease in patients with acute myocardial infarction. Methods Totally 291 patients with acute myocardial infarction diagnosed by coronary angiography were enrolled in this study. Serum total bilirubin (TBIL), total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and glycerol Triester (TG) level. The severity of coronary artery lesion was evaluated by the number of coronary lesion, the degree of coronary stenosis and the score of coronary lesion. Results The serum level of TBIL in patients with single vessel disease of acute myocardial infarction was significantly higher than that of patients with double vessel disease (p = 0.042) and three vessel lesions (p = 0.013). The level of serum TBIL was negatively correlated with the number of coronary lesions (p = 0.039). However, there was no significant difference in the serum TBIL levels between the two-vessel lesions of acute myocardial infarction and the three vessel lesions (p = 0.746). There was no significant correlation between serum TBIL level and coronary artery score. Conclusion The level of serum bilirubin may be related to the single vessel disease of acute myocardial infarction to a certain extent.