动脉粥样硬化是一种动脉的疾病。由于它是造成心肌和大脑梗死的主要原因,所以多年来已受到重视。但其病因和发病原理问题尚未解决。对这方面的研究,过去集中于一些危险因素(特别是高脂血症和高血压),以及从尸解或动物模型来观察此病的形态学和化学特征。近来才注意到动脉壁的病理生物学和平滑肌细胞增生对损害的形成起着关键作用。本文除了综合有关动脉平滑肌增生的基础的资料之外,还着重介绍关于动脉粥样硬化发病原理的三个现代假说。为此有必要先重温一 Atherosclerosis is a disease of the arteries. Since it is the main cause of myocardial infarction and myocardial infarction, it has been valued for many years. However, the etiology and pathogenesis of the problem has not yet been resolved. Research in this area has traditionally focused on a number of risk factors, particularly hyperlipidemia and hypertension, as well as the morphological and chemical features of the disease from autopsy or animal models. It has recently been noted that the pathophysiology of arterial walls and smooth muscle cell proliferation play a crucial role in the formation of lesions. In addition to synthesizing data on the basis of arterial smooth muscle proliferation, this article also focuses on three modern hypotheses on the pathogenesis of atherosclerosis. For this reason it is necessary to review one