作者前已证实牛种布氏菌内毒素制剂与大肠杆菌脂多糖(LPS)在免疫原性和其它辅佐性质方面是不同的。大肠杆菌 LPS 在对LPS 低反应性的 C3H/HeJ 小鼠中未引起明显的初次或二次性特异抗体反应,在协同基因的、对 LPS 有反应的 C3H/HeAu 小鼠中则产生了 IgM 和少量的 IgG 抗体。同时在胸腺机能正常和无胸腺的 BALB/C 小鼠中也引起了上述抗体的产生。与此相反,牛种布氏菌内毒素 The authors have previously demonstrated that B. bovis endotoxin preparations differ from E. coli lipopolysaccharide (LPS) in terms of immunogenicity and other adjunct properties. E. coli LPS did not cause significant primary or secondary specific antibody responses in LPS-deficient C3H / HeJ mice, whereas IgM and IgM were produced in synergistic genes in LPS-responsive C3H / HeAu mice Small amount of IgG antibody. The above antibodies were also elicited in both thymus-normal and athymic BALB / c mice. In contrast, bovine Brucella endotoxin