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据肿瘤起源两次突变假说,第二次突变可能为抗癌基因失活。这已在视网膜母细胞瘤、Wilms 瘤、结肠癌得到验证,它们均有恒定的特征性细胞遗传学异常。已知部分乳腺癌为显性遗传,并可能存在一种或多种乳腺癌抗癌基因,但由于乳腺癌细胞遗传学的研究较为困难,故对其特异性原发变化情况尚未完全阐明。乳腺癌细胞在长期培养中由于存在细胞优势生长的原因,正常二倍体较多,所以直接制片法有明显好处。本文报告了147例原发乳腺癌标本的直接法及同
According to the two mutation hypothesis of tumor origin, the second mutation may be the inactivation of anticancer genes. This has been demonstrated in retinoblastoma, Wilms’ tumor, and colon cancer, both of which have a constant characteristic cytogenetic abnormality. Some breast cancers are known to be dominantly inherited, and one or more breast cancer anticancer genes may be present. However, due to the difficulty in the study of breast cancer cell genetics, the specific changes of its specificity have not yet been fully elucidated. Due to the dominant cell growth in breast cancer cells in the long-term culture, there are many normal diploids, so the direct production method has obvious advantages. This article reports the direct method of 147 cases of primary breast cancer and the same