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目的分析儿科常见急性呼吸道感染性疾病患儿的血清超敏C反应蛋白(hs-CRP)检测结果,为临床诊断不同病原体感染,合理使用抗生素提供依据。方法随机抽取2011年1月—2013年12月于该科住院的急性上呼吸道感染、急性化脓性扁桃体炎、毛细支气管炎、支原体肺炎、非支原体肺炎、非感染疾病患儿各50例。对上述患儿资料的hs-CRP结果进行分析。结果不同组别hs-CRP水平不同,阳性率存在明显差异,χ2=104.88,P<0.01,阳性率从高至低依次为急性化脓性扁桃体炎、支原体肺炎、上呼吸道感染、非支原体肺炎、毛细支气管炎、非感染组。急性化脓性扁桃体炎的hs-CRP水平明显高于其他组别,阳性率组间比较,差异有统计学意义,P<0.01;毛细支气管患儿hs-CRP阳性率低于其他呼吸道感染组别,P值均<0.05,差异具有统计学意义。上呼吸道感染组、肺炎组、支原体肺炎组hs-CRP阳性率不同,但组间两两比较差异无统计学意义,P>0.05。结论临床医生需根据hs-CRP水平区分细菌感染和病毒感染,合理的使用抗生素。
Objective To analyze the results of serum hs-CRP in children with common acute respiratory infectious diseases and provide basis for clinical diagnosis of different pathogens and rational use of antibiotics. Methods A total of 50 children with acute upper respiratory tract infection, acute suppurative tonsillitis, bronchiolitis, mycoplasma pneumonia, non-mycoplasmal pneumonia and noninfectious disease were selected randomly from January 2011 to December 2013. The hs-CRP results of the above-mentioned pediatric data were analyzed. Results There were significant differences in hs-CRP levels between different groups (χ2 = 104.88, P <0.01). The positive rates were acute suppurative tonsillitis, mycoplasmal pneumonia, upper respiratory tract infection, non-mycoplasmal pneumonia, Bronchitis, non-infected group. The hs-CRP level in acute suppurative tonsillitis was significantly higher than that in other groups. There was significant difference between the two groups (P <0.01). The positive rate of hs-CRP in children with bronchiolitis was lower than that in other respiratory tract infection groups, P values were <0.05, the difference was statistically significant. The positive rates of hs-CRP in upper respiratory tract infection group, pneumonia group and mycoplasma pneumonia group were different, but there was no significant difference between the two groups (P> 0.05). Conclusion Clinicians need to distinguish bacterial infection and viral infection according to the level of hs-CRP, and make rational use of antibiotics.