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观察了雷公藤单体雷藤氯内酯醇 (T4)对雄性猕猴的抗生育作用及其可逆性. 1 2只性成熟雄性猴等分 4组 ,口服 T4剂量分别为 5 0、2 5、1 0、0μg? (kg? d) - 1,每周 6次 ,连续8周. 3个剂量组猕猴分别于给药第 8、7、5周其射出精液达到死精、无精、或严重寡精 (“,”The results of the preliminary observation on antifertility pharmacodynamics of tripchlorolide(T4) in male rhesus monkeys and reversibility of fertility after cessation of the treatment was reported.Twelve sexually mature male rhesus monkeys were randomly divided into 4 groups. T4 was adminstered orally at daily doses of 50, 25, 10, 0 μg/kg,6 times a week, for 8 consecutive weeks.Necrospermia, azoospermia or severe oligozoospermia(