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Rokitansky于1849年在急性肝坏死病人肝组织中发现了酪氨酸及亮氨酸结晶。其后发现肝病病人之酪氨酸代谢障碍,肝硬化病人有高酪氨酸血症。廿世纪五十年代证实了给人及动物输入无精氨酸的氨基酸(AA)混合液,可以促进肝性脑病的发生。反之,输给含精氨酸的AA混合液则可防止血氨的聚集及肝性脑病的发生。但是随着无选择性的应用AA治疗肝病,以及近廿年来生物化学的进展,发现了肝衰病人、特别是昏迷病人之血浆和神经系统存在AA的不平衡。因此,探讨AA与肝性脑病因果关系,进而应
Rokitansky found tyrosine and leucine crystals in liver tissue of patients with acute liver necrosis in 1849. Later found that patients with liver disease tyrosine metabolism disorders, cirrhosis patients with high tyrosinemia. The fifties of the 20th century confirmed the importation of arginine-free amino acids (AA) for humans and animals to promote the development of hepatic encephalopathy. Conversely, losing to AA containing arginine mixture can prevent the accumulation of blood ammonia and hepatic encephalopathy. However, with the indiscriminate application of AA in the treatment of liver disease and the progress of biochemistry in recent 20 years, it is found that there is an imbalance of AA in the plasma and nervous system of patients with liver failure, especially coma. Therefore, to explore the causal relationship between AA and hepatic encephalopathy, which should be