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自1961年Goffredo等在为一位心绞痛患者进行心导管检查时发现硝酸异山梨醇酯(ISDN)能扩张冠状血管以来,临床上用它来治疗心绞痛已有25年的历史了。然而,近年来发现此药对部分病人疗效有限。有时为控制心绞痛发作,不得不增加给药剂量和次数。近来有人研究用此药与其它药物合用治疗缺血性心脏病,以提高疗效,减少副作用。本文就这方面的现状作一综述。
Since 1961 Goffredo et al found that isosorbide dinitrate (ISDN) was able to dilate coronary vessels during cardiac catheterization of an angina patient and that it has been clinically used to treat angina for 25 years. However, in recent years, this drug has been found to have limited efficacy in some patients. Sometimes to control angina attacks, have to increase the dose and frequency. Recently, some people study the use of this drug in combination with other drugs for the treatment of ischemic heart disease in order to improve efficacy and reduce side effects. This article reviews the status quo in this area.