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目的：观察精制蝮蛇抗栓酶治疗小儿急性偏瘫的临床疗效。方法：１２８例急性小儿偏瘫患儿随机分为２组，对照组６４例给予低分子右旋糖酐１０ｍｌ·ｋｇ－１·ｄ－１加复方丹参注射液４～６ｍｌ静滴；治疗组６４例给予精制蝮蛇抗栓酶０．０１０～０．０１２Ｕ·ｋｇ－１·ｄ－１加生理盐水１００ｍｌ静滴。２组常规治疗相同，均以１４日为１个疗程，酌情用２～３个疗程。结果：治疗组总有效率（９５．３％）明显高于对照组（６８．８％），ｕ＝９．４６，Ｐ＜０．００１；病死率（３．１％）明显低于对照组（１２．５％），ｕ＝３．９１，Ｐ＜０．０５。经过２年的追踪随访，治疗组各种后遗症的发生率均明显低于对照组（Ｐ均＜０．０５）。结论：精制蝮蛇抗栓酶治疗小儿急性偏瘫临床疗效较好，优于传统扩血管剂，无明显不良反应，值得推广应用
Objective: To observe the clinical efficacy of purified viper snake antithrombin in the treatment of pediatric acute hemiplegia. Methods: A total of 128 children with acute pediatric hemiplegia were randomly divided into two groups. 64 cases in the control group were given low molecular dextran 10ml · kg-1 · d-1 plus 4 ~ 6ml intravenous infusion of compound Danshen injection. Serum antithrombin enzyme 0.010 ~ 0.012U · kg-1 · d-1 plus saline 100ml intravenous infusion. 2 groups of conventional treatment the same, are 14 days for a course of treatment, as appropriate, with 2 to 3 courses. Results: The total effective rate (95.3%) in the treatment group was significantly higher than that in the control group (68.8%), u = 9.46, P <0.001; the mortality rate was significantly lower than that in the control group (12.5%), u = 3.91, P <0.05. After 2 years of follow-up, the incidence of various sequelae in the treatment group was significantly lower than that in the control group (all P <0.05). Conclusion: The purified viper snake antithrombotic treatment of children with acute hemiplegia clinical efficacy is better than the traditional vasodilators, no significant adverse reactions, it is worth promoting the application