论文部分内容阅读
目的评价CA125在结核病诊断及判断治疗终点的价值,为结核病社区管理寻找新工具。方法选取2013年8月—2014年8月在深圳市龙岗区第三人民医院确诊为结核病的患者93例为结核病组,同时选取非结核病住院患者93例为对照组,使用化学发光法检测患者血清CA125水平,采用χ2检验比较2组间阳性率结果;对CA125阳性的结核病患者随访6个月,按照临床综合评估分为治愈组及非治愈组,复测血清CA125并评估其对非治愈组的诊断效能。结果结核病组血清CA125阳性率为68.8%(64/93),对照组CA125阳性率为57%(53/93),2组间差异无统计学意义(P>0.05);对64例CA125阳性的结核病患者随访6个月后,临床综合评估分为治愈组46例,非治愈组18例,CA125对非治愈组诊断敏感性为55.5%(10/18),特异性为100%(46/46),阳性预测值为100%(10/10),阴性预测值为85.1%(46/54),准确率为87.5%(56/64)。结论血清CA125对结核病的鉴别诊断价值不大,但对判断治疗终点有较大意义。CA125持续阳性应高度怀疑结核病未治愈,可作为社区传染病管理的随访指标。
Objective To evaluate the value of CA125 in diagnosing and judging the end point of tuberculosis and find new tools for community management of tuberculosis. Methods Ninety-three patients diagnosed as TB in the Third People’s Hospital of Longgang District from August 2013 to August 2014 were selected as the TB group. Ninety-three non-tuberculosis inpatients were selected as the control group. Chemiluminescence was used to detect serum CA125 levels, the positive rate ofχ2 test was used to compare the two groups of positive results; the CA125-positive tuberculosis patients were followed up for 6 months, according to the clinical comprehensive evaluation divided into cured and non-cured group, serum CA125 was measured and assessed for non-cured group Diagnostic efficiency. Results The positive rate of CA125 in tuberculosis group was 68.8% (64/93), while the positive rate of CA125 in control group was 57% (53/93). There was no significant difference between the two groups (P> 0.05) After 6 months of follow-up of TB patients, the clinical comprehensive evaluation was divided into 46 cases in the cured group and 18 cases in the non-cured group. The sensitivity and specificity of CA125 in non-cured group were 55.5% (10/18) and 100% (46/46) ), The positive predictive value was 100% (10/10), the negative predictive value was 85.1% (46/54), the accuracy rate was 87.5% (56/64). Conclusion Serum CA125 is of little value in the differential diagnosis of tuberculosis, but it is of great significance to judge the end point of treatment. Continued positive CA125 should be highly suspected tuberculosis is not cured, can be used as a follow-up of community infectious disease management indicators.