经皮腔内血管成形术是治疗股腘动脉硬化性病变的首选方法,术后较高的再狭窄率是临床亟待解决的问题.药物涂层球囊(DCB)作为一种新兴治疗手段,可抑制血管内膜增生及炎症反应,在股腘动脉硬化性病变的初次治疗及支架内再狭窄的治疗方面可明显降低晚期管腔丢失及靶病变血运重建率.此外,DCB联合斑块切除术、DCB联合金属支架植入术可改善股腘动脉重度狭窄的临床疗效.本文对近年来DCB在股腘动脉硬化性病变中的应用进展进行综述.“,”Percutaneous transluminal angioplasty is the preferred treatment of femoropopliteal arterial disease at present.But the high rate of restenosis needs to be solved rapidly.As a new treatment strategy,drug-coated balloon (DCB) can reduce the late lumen lose and the revascularization of target lesion by inhibiting intimal proliferation and inflammatory response,also it can treat femoropopliteal in-stent restenosis effectively.In addition,combining DCB and atherectomy or stenting can improve the outcomes for severe stenosis of femoropopliteal artery.The recent application progresses of DCB for femoropopliteal disease were reviewed in this article.