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目的:探讨赤雹果乙醇提取物(AETF)治疗继发性痛经的机制。方法:采用植入塑料管法,制备大鼠子宫内膜炎继发性痛经模型。观察AETF对模型大鼠子宫组织匀浆中一氧化氮(NO)、丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性的影响。结果:AETF 0.3,0.6,1.2 g.kg-1剂量组子宫组织匀浆中NO的含量明显低于模型组(P<0.01),SOD的活性明显高于模型组(P<0.05);0.6,1.2 g.kg-1剂量组子宫匀浆中MDA的含量明显低于模型组(P<0.01),GSH-Px的活性显著高于模型组(P<0.05)。结论:AETF治疗继发性痛经作用机制与抑制致炎致痛介质的产生和促进过氧化物的清除有关。
Objective: To investigate the mechanism of AETF in the treatment of secondary dysmenorrhea. Methods: The model of secondary dysmenorrhea in rat endometritis was prepared by implanting plastic tube. To observe the effect of AETF on the contents of NO and MDA and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the uterus tissue of model rats influences. Results: The content of NO in uterine homogenate of AETF 0.3, 0.6, 1.2 g.kg-1 dose group was significantly lower than that of model group (P <0.01) and SOD activity was significantly higher than that of model group (P <0.05) The content of MDA in 1.2 g.kg-1 dose group was significantly lower than that in model group (P <0.01), GSH-Px activity was significantly higher than that in model group (P <0.05). Conclusion: The mechanism of AETF in treating secondary dysmenorrhea is related to inhibiting the production of inflammatory mediators and promoting the clearance of peroxides.