50年代,美国首先用吡嗪酰胺(PZA)和INH对鼠结核病治疗有高效灭菌作用。临床大剂量PZA(50mg/kg)与INH联用也是一个有效方案,但对肝毒性较大未被采用。严重病例PZA给与较小剂量20～30mg/kg,不能阻止细菌对INH的耐药,由于它不能有效抑制病灶中的结核菌,故多年来仅作为治疗的后备药。现在应用PZA和RFP短程化疗证明不仅大量杀死 In the 1950s, the United States used pyrazinamide (PZA) and INH to sterilize mouse tuberculosis effectively. Clinical high-dose PZA (50mg / kg) combined with INH is also an effective regimen, but not for the greater use of hepatotoxicity. Severe cases of PZA given a smaller dose of 20 ~ 30mg / kg, can not stop the bacterial resistance to INH, because it can not effectively inhibit the tuberculosis in the lesion, so only for many years as a treatment of the backup drug. Now the use of PZA and RFP short-course chemotherapy proved not only killed in large numbers