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目的:观察辛伐他汀治疗心绞痛合并慢性肾功能不全的疗效与安全性。方法:在原有冠心病、慢性肾功能不全常规药物治疗基础上加用辛伐他汀,观察临床症状、肾功能等指标。结果:治疗组心绞痛发作次数及硝酸甘油用量均较对照组明显减少(P<0.05),6个月后,治疗组SCr明显下降、CCr明显上升(P<0.01),两组比较肾保护作用治疗组明显优于对照组。结论:他汀类药物可辅助其他药物治疗冠心病,同时具有肾保护作用。
Objective: To observe the efficacy and safety of simvastatin in the treatment of angina pectoris with chronic renal insufficiency. Methods: Simvastatin was added on the basis of conventional coronary heart disease and chronic renal insufficiency. The clinical symptoms and renal function were observed. Results: The number of angina pectoris and the dosage of nitroglycerin in the treatment group were significantly lower than those in the control group (P <0.05). After 6 months, the SCr in the treatment group decreased significantly and the CCr increased significantly (P <0.01) Group was significantly better than the control group. Conclusion: Statins can help other drugs in the treatment of coronary heart disease, at the same time with renal protection.