目的 :探讨人免疫器官突触体素、S -1 0 0蛋白和神经特异性烯醇化酶 (NSE)免疫反应神经纤维的支配和免疫反应细胞的分布 ,为神经内分泌和免疫系统相互作用提供形态学资料。方法 :应用免疫组织化学ABC法观察正常免疫器官包括胸腺、脾脏、淋巴结各 3 0例。 1 0 %福尔马林固定 ,石蜡包埋。结果 :胸腺 ,突触体素、S -1 0 0蛋白和NSE免疫反应神经纤维从胸腺被膜随小叶间隔和血管到胸腺皮质 ,再延伸到髓质形成神经纤维网 ,在胸腺组织散在分布突触体素、S -1 0 0蛋白和NSE免疫反应细胞。淋巴结 ,免疫反应神经纤维沿被膜和门部结缔组织小梁及血管进入皮质后主要分布于副皮质区环绕淋巴滤泡 ,进一步分支到达髓质。在髓质髓窦内有NSE免疫反应细胞。脾脏 ,免疫反应神经纤维沿着血管的各级分支进入脾实质 ,主要沿着脾动脉的分支而分布在白髓、红髓和边缘区 ,穿插于淋巴细胞之间。结论 :在人免疫器官可能存在神经内分泌免疫系统相互作用和调控 OBJECTIVE: To investigate the distribution of immunodominant nerve cells and the distribution of synaptophysin, S-100 protein and NSE immunoreactive nerve fibers in human immune organs and to provide morphological evidence for the interaction between neuroendocrine and immune system Learn information Methods: Immunohistochemical ABC method was used to observe the normal immune organs including thymus, spleen and lymph nodes in 30 cases. 10% formalin fixed, paraffin embedded. RESULTS: The thymus, synaptophysin, S-100 protein and NSE immunoreactive nerve fibers extended from the thymus envelope to the thymus cortex and then extended to the medulla to form the nerve fiber network, scattered in the thymus Voxel, S-100 protein and NSE immunoreactive cells. Lymph nodes, immune reaction nerve fibers along the capsule and portal connective tissue trabeculae and blood vessels into the cortex are mainly distributed in the para-cortical area around the lymphoid follicles, and further branch to reach the medulla. NSE immunoreactive cells in the medulla medulla. The spleen, the immunoreactive nerve fiber, enters the splenic parenchyma along all branches of the blood vessel, interspersed mainly in the white pulp, the red pulp and the marginal zone, along the branches of the splenic artery, interspersed with lymphocytes. Conclusion: There may be neuroendocrine immune system interactions and regulation in human immune organs