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恶性肿瘤是一种严重危害人类生命和健康的疾病,而致瘤性DNA病毒是多种恶性肿瘤的主要致病因子.致瘤性DNA病毒的整合可以使宿主细胞正常组织逐步向炎症组织转变,并可导致癌变.病毒整合可引起宿主细胞基因组不稳定和重排,产生新的融合基因,并导致宿主基因表达异常,也是病毒本身得以复制,逃避宿主免疫识别并长期维系自我生存的机制之一.本文综述了目前对致瘤性DNA病毒整合规律以及致瘤性DNA病毒整合致瘤效应的研究和进展,并展望致瘤性DNA病毒整合的研究方向以及在肿瘤发生、发展、诊断和治疗上的应用前景.
Malignant tumor is a serious disease that endangers human life and health, and tumorigenic DNA virus is the main virulence factor of many malignant tumors.The integration of tumorigenic DNA virus can make host cell normal tissue gradually transform to inflammatory tissue, And can lead to cancer.Viral integration can lead to host cell genome instability and rearrangement, resulting in a new fusion gene, and lead to host gene expression abnormalities, but also the virus itself can be copied, evade host immune recognition and long-term maintenance of self-survival mechanism This review summarizes the current research progress on the integration of oncogenic DNA viruses and the oncogenic effect of tumorigenic DNA viruses, and looks into the research direction of the integration of oncogenic DNA viruses and its application in tumorigenesis, development, diagnosis and treatment The application prospects.