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目的:初步探讨射波刀在原发性肝癌治疗中的效果及并发症。方法:选择2007年12月至2012年12月收治的原发性肝癌328例,其中男性288例,女性40例,年龄21~79岁,平均52.5岁。采用射波刀治疗,分割1~10次,平均4.35次,照射剂量24.5~52Gy,平均42.7Gy,剂量曲线从56%~90%,平均69.3%。结果:随访6个月至74个月,平均22个月。按照mRECIST标准,治疗后6个月复查CT/MR,局部完全缓解(CR)29例(8.8%)、部分缓解(PR)201例(61.3%)、稳定(SD)63例(19.2%)、进展(PD)35例(10.7%),中位无进展生存14.38个月,总生存17.3个月。结论:射波刀治疗原发性肝癌是一种有效和安全的治疗模式。
Objective: To explore the effect and complications of wave knife in the treatment of primary liver cancer. Methods: A total of 328 cases of primary liver cancer were selected from December 2007 to December 2012, including 288 males and 40 females, aged from 21 to 79 years with an average age of 52.5 years. The patients were treated with radiosurgery and divided into 1 to 10 times with an average of 4.35 times. The irradiation dose was 24.5-52 Gy with an average of 42.7 Gy. The dose curve ranged from 56% to 90% with an average of 69.3%. Results: The follow-up ranged from 6 months to 74 months with an average of 22 months. According to the mRECIST criteria, CT / MR were reviewed at 6 months after treatment. Twenty-nine patients (8.8%) had partial complete response (CR), 201 patients (61.3%) had partial response (PR) and 63 patients (19.2% Progress (PD) in 35 cases (10.7%), median progression-free survival of 14.38 months, the total survival of 17.3 months. Conclusion: The treatment of primary hepatocellular carcinoma with an electric knife is an effective and safe treatment model.