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为探讨急性原发性闭角型青光眼（ＰＡＣＧ）及其小梁切除术后角膜内皮细胞（ＣＥＣ）的形态计量学变化和临床意义。对３６例ＰＡＣＧ患者于小梁切除术前和术后３个月进行了角膜内皮细胞观察和图象分析。结果：与正常人相比，ＰＡＣＧ患者ＣＥＣ密度、形状系数明显减小，面积、周长、长径、变异系数增大（Ｐ＜０．０１）。无并发症的小梁切除术未使ＣＥＣ发生形态计量学变化。而术后浅前房者与术前相比ＣＥＣ密度和形状系数进一步减小。面积、周长、长径和变异系数进一步增大。结论：ＰＡＣＧ患者ＣＥＣ处于不稳定状态，应尽早控制眼压，在选择小梁切除术时防治术后浅前房对保护ＣＥＣ十分重要
To investigate the morphological changes and clinical significance of corneal endothelial cells (CEC) after acute primary angle-closure glaucoma (PACG) and trabeculectomy. Corneal endothelial cell observation and image analysis were performed on 36 patients with PACG before trabeculectomy and 3 months after surgery. Results: Compared with normal controls, the CEC density and shape coefficient of PACG patients were significantly decreased, and the area, perimeter, major axis and coefficient of variation were increased (P <0.01). Histopathological changes did not occur in CEC without trabeculectomy. The postoperative shallow anterior chamber compared with preoperative CEC density and shape factor further reduced. Area, perimeter, major axis and coefficient of variation were further increased. CONCLUSIONS: The CEC in PACG patients is in an unstable state and the intraocular pressure should be controlled as soon as possible. Prevention and treatment of shallow anterior chamber after selective trabeculectomy is very important for the protection of CEC