本文全面地考虑了液相色谱体系中溶质和溶剂、溶质和固定相,溶剂和固定相分子之间的各种相互作用和不同种类溶剂分子在固定相表面上的竞争吸咐,提出了一个具有四组参数的溶质在液相色谱中的计量置换保留模型。以文献及实验数据对此模型进行了验证。结果表明,对不同的流动相和不同的固定相体系,在多组分全浓度范围内,此模型都能良好地描述实验事实。 In this paper, all kinds of interactions between solute and solvent, solute and stationary phase, solvent and stationary phase molecules and competitive adsorption of different kinds of solvent molecules on the surface of stationary phase are considered in the liquid chromatography system. Four groups of parameters of solute in liquid chromatography in the metered displacement retention model. The model was verified by literature and experimental data. The results show that for different mobile phases and different stationary phase systems, this model can well describe the experimental facts in the full range of multiple components.