国产环硫雄醇系由龙舌兰制麻废液中提取合成。小鼠腹腔注射环硫雄醇,急性毒性LD_(50)1469mg/kg。大鼠亚急性毒性,高剂量(100ms/kg)腹腔注射,子宫内膜明显增殖,卵泡成熟受抑制。300mg/kg腹腔注射,对小鼠乳腺癌有明显抑制。0.5mg/只肌肉注射,对小鼠有明显抗雌激素活性和抗着床作用。2.5mg/只肌肉注射,可增强大鼠子宫孕激素活性,组织化学显示子宫内膜上皮和腺细胞的β-葡萄糖苷酸酶、酸性磷酸酶和碱性磷酸酶反应减弱。 Domestic thiosterols were extracted and synthesized from the agave waste. Mice were intraperitoneally injected with thioxanthol, and the acute toxicity was LD_(50)1469mg/kg. Rat sub-acute toxicity, high dose (100ms/kg) intraperitoneal injection, endometrial proliferation, follicular maturation was inhibited. 300mg/kg intraperitoneal injection, significant inhibition of mouse breast cancer. Intramuscular injection of 0.5 mg/m has significant anti-estrogen activity and anti-implantation effects in mice. Intramuscular injection of 2.5 mg/kg intramuscularly increased the uterus’s progesterone activity. Histochemistry showed that the β-glucuronidase, acid phosphatase and alkaline phosphatase responses in endometrial epithelium and glandular cells were weakened.