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目的探讨羟苯磺酸钙联合贝那普利治疗糖尿病肾病的临床疗效。方法 2009年1月至2011年1月诊治的符合入选标准糖尿病肾病患者186例,分为综合治疗组96例和对照组90例,观察治疗效果。结果两组病例治疗前、后24 h尿蛋白排漏率(24 h UAE)、血肌酐(Scr)、尿素氮(BUN)比较,差异有统计学意义(P<0.05)。结论羟苯磺酸钙联合贝那普利治疗糖尿病肾病调节微血管壁的生理功能,抑制血小板聚集,降低血黏滞度,降低肾小球内高压,降低肾小球基底膜的通透性,达到良好的控制糖尿病肾病的效果。
Objective To investigate the clinical efficacy of calcium dobesilate and benazepril in the treatment of diabetic nephropathy. Methods A total of 186 patients with diabetic nephropathy who met the criteria of diagnosis and treatment from January 2009 to January 2011 were divided into treatment group (96 cases) and control group (90 cases). The therapeutic effect was observed. Results The urinary protein excretion rate (24 h UAE), serum creatinine (Scr), blood urea nitrogen (BUN) in the two groups before and after treatment were significantly different between the two groups (P <0.05). Conclusion Calcium dobesilate and benazepril treatment of diabetic nephropathy regulate the physiological function of microvascular wall, inhibit platelet aggregation, reduce blood viscosity, reduce glomerular hypertension, reduce glomerular basement membrane permeability and achieve Good control of diabetic nephropathy.