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造血干细胞移植成功的关键在于造血干细胞和基质细胞的质和量。移植前大剂量化疗和放疗预处理不仅破坏造血干细胞,并且也严重破坏基质细胞。为了加快重建造血,提高成功率,我们观察了外周血干细胞(PBSC)和基质祖细胞(MPC)联合移植的造血重建。现将结果报告如下。
The key to successful hematopoietic stem cell transplantation is the quality and quantity of hematopoietic stem cells and stromal cells. Pre-transplant high-dose chemotherapy and radiotherapy pre-treatment not only destroy hematopoietic stem cells, but also severely damage stromal cells. In order to speed up the reconstruction of hematopoiesis and improve the success rate, we observed the hematopoietic reconstitution of peripheral blood stem cells (PBSC) and stromal progenitor cells (MPC). The results reported below.