论文部分内容阅读
目的 观察神经母细胞瘤的血管形成及影响因素 ,探讨化疗对神经母细胞瘤血管形成的作用。方法 3 5例小儿实体肿瘤 ,年龄 7月～ 12岁 ,分神经母细胞瘤组、其他恶性肿瘤组和良性肿瘤组 ,分别用免疫组化法观察第VIII因子相关抗原 (VWF)、内皮细胞生长因子 (VEGF)及其受体FLT 1的表达情况 ,并行图象分析。结果 神经母细胞瘤血管密度较良性肿瘤组明显增高 (P <0 .0 5 ) ;VEGF和FLT 1在神经母细胞瘤中有高表达 ,二者均与临床分期和分类有关 ,并可受化疗的抑制 (P <0 .0 5 )。结论 神经母细胞瘤生长具有血管依赖性 ,化疗可抑制血管形成 ,控制肿瘤血管形成对抑制肿瘤的生长和转移有积极意义。
Objective To observe the angiogenesis of neuroblastoma and its influencing factors and to explore the effect of chemotherapy on the angiogenesis of neuroblastoma. Methods Twenty-five pediatric solid tumors, aged from 7 to 12 years old, divided into neuroblastoma group, other malignant tumor group and benign tumor group, were immunohistochemically observed for the expression of factor VIII-related antigen (VWF), endothelial cell growth Factor (VEGF) and its receptor FLT 1 expression, parallel image analysis. Results The neuronal cell density of neuroblastoma was significantly higher than that of benign tumor (P <0.05). VEGF and FLT 1 were highly expressed in neuroblastoma, both of which were related to clinical stage and classification and could be affected by chemotherapy (P <0.05). Conclusions Neuroblastoma is angiogenic. Chemotherapy can inhibit the formation of blood vessels. Controlling the formation of tumor blood vessels has a positive effect on the inhibition of tumor growth and metastasis.