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目的:观察不同孕周早产儿解脲支原体(UU)感染情况及红霉素治疗的疗效。方法:选择符合要求的早产儿进行痰培养UU检测,检出69例UU阳性患儿,并将患儿根据孕周分成三组,分别设孕28周-为C1组,孕32周-为C2组,孕35周-为C3组。对不同组段UU感染的阳性率进行比较。同时对30例患儿经过红霉素治疗的命名为红霉素治疗组,39例未进行红霉素治疗的命名为对照组,分别行血常规、胸片、白介素-6(IL-6)、白介素-8(IL-8)的检测。结果:C2组患儿UU感染率最高,C1组患儿UU-DNA拷贝值最高。红霉素治疗组和对照组相比,血白细胞总数及IL-6、IL-8呈下降趋势。结论:早产儿UU感染在孕32周-感染率最高,有必要对符合要求的病例进行红霉素治疗。
Objective: To observe the prevalence of UU in different gestational weeks of preterm infants and the effect of erythromycin treatment. Methods: 69 cases of UU-positive children were selected and tested for sputum culture UU. The children were divided into three groups according to their gestational age, and they were pregnant for 28 weeks - C1 group and 32 weeks pregnant - C2 Group, pregnant 35 weeks - for the C3 group. The positive rates of UU infection in different groups were compared. At the same time, 30 cases of erythromycin-treated erythromycin group were treated with erythromycin, and 39 cases without erythromycin were given as control group. Blood routine, chest radiograph, interleukin-6 (IL-6) , Interleukin -8 (IL-8) detection. Results: The infection rate of UU in C2 group was the highest, while that in C1 group was the highest. Erythromycin treatment group compared with the control group, the total number of white blood cells and IL-6, IL-8 showed a downward trend. CONCLUSIONS: UU infection in preterm infants at 32 weeks of gestation - the highest infection rate - is necessary for erythromycin treatment in eligible patients.