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乙肝病毒(HBV)慢性感染可发展成肝癌,这在流行病学上已有结论,但HBV整合对细胞恶化的直接作用则证据极少。本文作者克隆了一个早期肝癌的HBV整合部位。以噬菌体cDNA库探针法和计算机研究得知HBV整合部位的蛋白质C-端半边有150个氨
Hepatitis B virus (HBV) chronic infection can develop into liver cancer, which has been concluded in epidemiology. However, the direct effect of HBV integration on cell deterioration has little evidence. The authors cloned an HBV integration site for early hepatocellular carcinoma. The phage cDNA library probe method and computer studies have revealed that there are 150 ammonia in the C-terminal half of the protein at the site of HBV integration.