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目的:评价延生口服液对吗啡依赖性大鼠模型脱毒治疗作用。方法:采用剂量递增法皮下注射吗啡14 d和30 d,分别建立大鼠吗啡依赖模型,观察延生口服液大、中、小3个剂量对纳洛酮催促和自然戒断的吗啡依赖大鼠戒断症状及体重的影响。结果:延生口服液能显著减轻吗啡依赖大鼠ip纳洛酮引起的催促戒断症状(P<0.05)和体重下降(P<0.01),不能明显抑制自然戒断大鼠体重下降(P>0.05)。结论:延生口服液对吗啡依赖性大鼠戒断后所产生的戒断综合征具有明显的脱毒治疗作用。
Objective: To evaluate the effect of Yansheng oral liquid on the detoxification of morphine-dependent rat model. METHODS: Morphine dependence model was established by subcutaneous injection of morphine for 14 days and 30 days, respectively, using a dose escalation method. The morphine dependence of naloxone-induced morphine-dependent rats was observed in large, medium, and small doses of Yansheng Oral Liquid. Symptoms and weight effects. RESULTS: Yansheng Oral Liquid could significantly reduce the morphine withdrawal-induced naloxone-induced withdrawal symptoms (P<0.05) and weight loss (P<0.01), but could not significantly inhibit the weight loss of spontaneous withdrawal rats (P>0.05). ). Conclusion: Yansheng Oral Solution has a detoxifying effect on morphine-dependent withdrawal syndrome.