论文部分内容阅读
目的探讨人工肝血浆置换术(PE)治疗慢性重症肝炎的疗效。方法121例慢性重症肝炎患者在内科综合治疗基础上配合血浆置换,共183例次,观察其治疗前后的临床症状、肝功能、PT及HBV血清标志物,HBV-DNA改变情况,探讨其与预后的内在关联。结果121例慢性重型肝炎患者经血浆置换治疗后,临床症状都得到一定程度的改善,肝功能明显好转。临床好转率为64.46%(78/121),其中早期83.78%,中期46.87%,晚期6.66%,同时1次与多次人工肝治疗临床好转率比较后者明显高于前者,二者比较有较显著性差异。结论血浆置换对于慢性重型肝炎是一种安全有效的治疗方法,早期及无严重并发症的治疗疗效好。
Objective To investigate the curative effect of artificial liver plasma exchange (PE) on chronic severe hepatitis. Methods A total of 183 cases of 121 patients with chronic severe hepatitis were treated with plasma exchange on the basis of comprehensive medical treatment. Clinical symptoms, liver function, PT, serum HBV markers and HBV-DNA changes were observed before and after treatment. The inner relationship. Results After 121 patients with chronic severe hepatitis were treated by plasma exchange, the clinical symptoms were improved to a certain extent, and the liver function improved obviously. The clinical improvement rate was 64.46% (78/121), of which 83.78% in the early stage, 46.87% in the middle stage and 6.66% in the late stage, and the latter was significantly higher than the former in the clinical improvement rate of multiple artificial liver therapy Significant difference. Conclusion Plasma exchange is a safe and effective treatment for chronic severe hepatitis, with early and no serious complications.