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目的:观察更年安胶囊联合戊酸雌二醇片治疗肾阴虚型围绝经期综合征的临床疗效,及对患者血清性激素水平的影响。方法:选取本院112例肾阴虚型围绝经期综合征患者,随机分为观察组与对照组各56例。对照组给予戊酸雌二醇片治疗,观察组在对照组用药基础上联合更年安胶囊治疗。比较2组治疗总有效率,观察2组治疗前后血清雌二醇(E_2)、卵泡刺激素(FSH)、促黄体生成素(LH)水平的变化和治疗期间的不良反应发生情况。结果:观察组治疗总有效率92.86%,高于对照组的73.21%(P<0.01)。治疗后,2组E_2水平均较治疗前升高(P<0.05),FSH及LH水平均较治疗前降低(P<0.05);观察组E_2水平较对照组升高更明显(P<0.05),FSH及LH水平均较对照组下降更明显(P<0.05)。观察组不良反应发生率8.93%,对照组不良反应发生率23.21%,2组比较,差异有统计学意义(P<0.05)。结论:更年安胶囊联合戊酸雌二醇片治疗肾阴虚型围绝经期综合征,可有效改善患者的血清性激素水平,提高临床疗效,且安全性较高,值得在临床推广应用。
Objective: To observe the clinical efficacy of Gengnian-An Capsule combined with estradiol valerate tablets in the treatment of perimenopausal syndrome with kidney-yin deficiency and its effect on serum sex hormone levels. Methods: A total of 112 patients with kidney-yin deficiency perimenopausal syndrome in our hospital were randomly divided into observation group and control group with 56 cases each. The control group was given estradiol valerate tablets. The observation group was treated with Gengnian’an capsule on the basis of the control group. The total effective rate of the two groups was compared. The changes of serum estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) and the adverse reactions during the treatment were observed before and after treatment. Results: The total effective rate in the observation group was 92.86%, which was higher than that in the control group (73.21%, P <0.01). After treatment, the levels of E2 in both groups were significantly higher than those before treatment (P <0.05), while the levels of FSH and LH were lower than those before treatment (P <0.05). The E_2 level in the observation group was significantly higher than that in the control group (P <0.05) , FSH and LH levels decreased more significantly than the control group (P <0.05). The incidence of adverse reactions in the observation group was 8.93%, and the incidence of adverse reactions in the control group was 23.21%. There was significant difference between the two groups (P <0.05). Conclusion: Gengnian’an capsule combined with estradiol valerate tablets in the treatment of perimenopausal syndrome with deficiency of the kidney can effectively improve the level of serum sex hormones, improve the clinical curative effect and have higher safety. It is worthy of clinical application.