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目的:了解乙肝病毒入侵肝细胞的临床研究现状。方法:查阅文献,汇总资料中关于乙肝病毒入侵肝细胞的环节、病毒的结构及生命周期及乙肝病毒入侵的细胞分子等观点,从而了解乙肝病毒入侵肝细胞入侵点、机制等。结果:HBV的宿主特性和嗜肝性与肝细胞受体有关,病毒入侵肝细胞的关键部位是表面抗原前S1区,在S1区与其特异性结合的受体是NTCP。结论:全面深入研究HBV入侵肝细胞的分子机制,阻断病毒入侵,一直是临床研究的重点,也将为慢性HBV感染的防治提供巨大帮助。
Objective: To understand the clinical status of hepatitis B virus invaded hepatocytes. Methods: To review the literature, summarize the data on the hepatitis B virus invasion of hepatocytes, the structure and life cycle of the virus and hepatitis B virus invasion of cellular molecules point of view, in order to understand the hepatitis B virus invasion of hepatocytes invasion point mechanism. Results: The host characteristics and hepatotoxicity of HBV were related to the hepatocyte receptors. The key part of the virus-infected hepatocytes was the pre-S1 region of surface antigen, and the receptor specifically bound to it in S1 region was NTCP. Conclusion: It is always the focus of clinical research to thoroughly investigate the molecular mechanism of HBV invasion of hepatocytes and block the virus invasion. It will also provide great help for the prevention and treatment of chronic HBV infection.