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目的观察缩宫素鼻喷雾剂在药物流产中的应用效果。方法将300例无药物流产禁忌证、自愿要求终止妊娠的患者随机分为观察组和对照组各150例,两组均采用米非司酮联合米索前列醇行药物流产术,观察组在口服米索前给予缩宫素鼻喷雾剂,左、右侧鼻腔各1喷(共8个单位),术后每日4次,连用3天;两组术后均加用益母草颗粒,比较两组患者孕囊排出时间、药物流产有效率及药物流产术后阴道出血情况。结果两组患者在孕囊排出时间、药物流产有效率及药物流产术后阴道出血情况差异有统计学意义(P<0.05)。结论缩宫素鼻喷雾剂应用于药物流产能明显缩短孕囊排出时间,提高药物流产有效率,减少阴道出血时间,值得临床推广。
Objective To observe the effect of oxytocin nasal spray in medical abortion. Methods 300 cases of drug abortion contraindications, voluntary termination of pregnancy were randomly divided into observation group and control group of 150 cases, both groups were using mifepristone combined with misoprostol drug abortion, the observation group in the oral Misoprostol nasal spray before administration of misoprostol, left and right nasal spray 1 (a total of 8 units), 4 times a day for 3 days once a day; both groups were treated with Motherwort granules, compared two groups Patients with gestational sac discharge time, the effectiveness of medical abortion and vaginal bleeding after medical abortion. Results The two groups of patients in the gestational sac discharge time, the effective rate of medical abortion and vaginal bleeding after medical abortion were statistically significant (P <0.05). Conclusion The application of oxytocin nasal spray in medical abortion significantly shortened the discharge of gestational sac, improved the efficiency of medical abortion and reduced the time of vaginal bleeding, which is worthy of clinical promotion.