核心蛋白聚糖为一富含亮氨酸的小分子蛋白聚糖 ,是细胞外基质的组成成分 ,与胶原纤维紧密相连 ,广泛分布于人和动物的肌腱、皮肤、骨、软骨、脐带、韧带及角膜等各种组织。近十几年的研究表明 ,它可与TGF β结合 ,并中和TGF β的所有生物学活性 ,因此在TGF β过度表达引起的脏器纤维化的防治中有着广泛的应用前景 Decorin is a leucine-rich small molecule proteoglycan that is a component of extracellular matrix closely linked to collagen fibers and widely distributed in tendons, skins, bones, cartilages, umbilical cord and ligaments of humans and animals And corneal and other organizations. Nearly ten years of research have shown that it can bind to TGFβ and neutralize all biological activities of TGFβ, so it has a broad application prospect in the prevention and treatment of organ fibrosis caused by TGFβ overexpression