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为了观察甲状腺调节因子如细胞因子、激素及神经递质对甲状腺细胞(TEC)细胞间粘附分子-1(ICAM-1)表达的影响,本研究在细胞培养基础上,采用ELISA法检测不同因子刺激后细胞上清液中可溶性ICAM-1(sICAM-1)的含量。结果表明:(1)细胞因子IL-1、IL-6可显著抑制TEC sICAM-1的合成,而TNF-α和IFN-γ则明显刺激sICAM-1产生;(2)肾上腺素、去甲肾上腺素、乙酰胆碱均可显著抑制TEC分泌sICAM-1;(3)促甲状腺素和地塞米松可显著抑制sICAM-1的生成;而泌乳素和雌激素则明显促进sICAM-1的产生。提示甲状腺调节因子可通过影响ICAM-1表达,参与甲状腺局部免疫调节过程。
In order to observe the effects of thyroid regulators such as cytokines, hormones and neurotransmitters on the expression of intercellular adhesion molecule-1 (ICAM-1) in thyrocytes (TECs), the effects of different factors The content of soluble ICAM-1 (sICAM-1) in the cell supernatant after stimulation. The results showed that: (1) The cytokines IL-1 and IL-6 could significantly inhibit the synthesis of TEC sICAM-1, whereas TNF-α and IFN-γ significantly stimulated the production of sICAM-1; (2) Adrenaline, (3) Thyroxine and dexamethasone can significantly inhibit the production of sICAM-1, while prolactin and estrogen significantly promote the production of sICAM-1. It is suggested that thyroid regulators may participate in the thyroid local immune regulation by affecting the expression of ICAM-1.