目前,优降糖已广泛用于治疗非胰岛素依赖型糖尿病(NIDDM),疗效肯定,其主要副作用为低血糖症.尤其于老年人和/或心肾功能损害者更易发生。我科自1988年2月～1989年4月共收治5例,均为优降糖诱发的长时间低血糖症,其中2例遗有严重脑功能不全后遗症,摘要报告并对其诱发因素、临床特点及处理原则加以讨论。 Currently, glyburide has been widely used in the treatment of non-insulin-dependent diabetes mellitus (NIDDM), the curative effect is affirmed, the main side effect is hypoglycemia, especially in the elderly and / or heart and kidney dysfunction are more likely to occur. Our department from February 1988 to April 1989 were treated in 5 cases, are hypoglycemic-induced long-term hypoglycemia, of which 2 left with severe brain dysfunction sequelae, the summary report and its predisposing factors, clinical Features and principles to be discussed.