塞来昔布联合帕瑞昔布钠在全膝关节置换围手术期的效果

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目的观察塞来昔布联合帕瑞昔布钠术前预处理对类风湿关节炎(RA)全膝关节置换术(TKA)术后镇痛效果及炎性因子的影响。方法选取行TKA的RA患者83例,随机分为超前镇痛组(41例)和对照组(42例),超前镇痛组术前24、12 h给予塞来昔布,术前30 min给予帕瑞昔布钠;对照组给予安慰剂,2组患者均给予硬膜外麻醉,术后给予自控硬膜外镇痛(PCEA)。记录不同时间点、时间段2组患者的视觉模拟评分法(VAS)评分、术后按压镇痛泵次数及口服氨酚羟考酮补救止痛剂量;记录不同时间点2组患者的白细胞介素-6(IL-6
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