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采用 ̄(99m)Tc-ccM4McAb对10例胃癌病人、4例非胄癌病人进行放射免疫显像(RIS)研究,观察了血清TAG-72抗原量、抗体注入量对RIS阳性检出率的影响。结果表明注入 ̄(99m)Tc-ccM4后,胃癌阳性检出率60%,肝转移阳性检出率50%,全部良性病变显示阴性结果。注入抗体8h后为最佳显像时间,给予一定量抗体后,增加抗体用量并不提高RIS的阳性检出率。血清TAG-72抗原含量与RIS肿瘤阳性检出率明显相关。
A radioimmunoscintigraphy (RIS) study was performed on 10 patients with gastric cancer and 4 patients with non-cancer cancer using ̄(99m)Tc-ccM4McAb. The effect of serum TAG-72 antigen and antibody injection on the positive rate of RIS was observed. . The results showed that after injecting ̄(99m)Tc-ccM4, the positive rate of gastric cancer was 60%, and the positive rate of liver metastasis was 50%. All benign lesions showed negative results. The optimal imaging time was 8 h after the injection of antibody. After a certain amount of antibody was administered, increasing the amount of antibody did not increase the positive detection rate of RIS. The serum TAG-72 antigen content was significantly correlated with the positive rate of RIS tumor detection.