近二十年来,虽然对新生儿细菌性脑膜炎的发病机理有了更多的认识,新的抗菌素也不断出现,可是按照常用的全身给药疗法,其病死率和神经系统合并症的发生率仍高。辅以鞘内给药也未能改善预后。问题在于忽视了新生儿脑膜炎往往伴有脑室炎,而全身给药不能使有些抗菌素在脑室的脑脊液中达到有效浓度。Lorber 等认为其浓度必须高于最小抑菌浓度50倍方可见效。这只有将 In the recent two decades, new antibiotics have emerged more and more although the pathogenesis of bacterial meningitis in neonates has been recognized more and more. However, according to the commonly used systemic drug therapy, the incidence of mortality and neurological complications Still high. Combined with intrathecal administration also failed to improve the prognosis. The problem is that ignoring neonatal meningitis is often associated with intraventricular volvulus, whereas systemic administration does not allow some antibiotics to reach an effective concentration in the cerebrospinal fluid of the ventricles. Lorber so that its concentration must be higher than the minimum inhibitory concentration of 50 times before effective. This will only be