本文首次建立了对伯氨喹Primaquine PQ(脂质体的制备方法——二次乳化法,研制成伯氨喹脂质体LPQ;比较了伯氨喹脂质体与游离伯氨喹的抗疟原虫红外期作用,同时也观察了给小鼠腹腔注射环磷酰胺CP与植物血凝素PHA后的伯氨喹脂质体对约氏疟原虫红外期的作用效果。 二次乳化法制备伯氨喹脂质体效果较佳,具有高包封率、工艺简单、不需加热等特点。应用电子显微镜观察合成的伯氨喹脂质体多呈圆形或椭圆形的空 This article for the first time established the primaquine Primaquine PQ (liposome preparation method - the second emulsification method, developed into primaquine liposome LPQ; compared the primaquine liposomes and free primaquine antimalarial Protozoa IR role, but also observed the intraperitoneal injection of cyclophosphamide CP and phytohemagglutinin PHA after primaquine liposomes of Plasmodium yoelii IR effect .Effects of secondary emulsion preparation of primary ammonia Quinidine liposomes have better effect, with high entrapment efficiency, simple process, without heating, etc .. The observation of the electron microscopy of primaine quinine liposomes mostly round or oval-shaped empty