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目的探讨不同年龄段女性HPV易感性,并分析不同HPV亚型在聊城地区的分布特点及致宫颈上皮内瘤变作用差异。方法选取2014年8月-2015年12月医院因宫颈疾病就诊3 095例患者,进行过HPV分型检测,对阳性患者进行宫颈细胞学检查或阴道镜活检,数据采用SPSS 17.0软件进行统计分析。结果 HPV阳性患者830例,占26.82%;以30~49岁年龄段HPV感染为主,占31.20%;宫颈高级别病变患者中检出最多的HPV亚型前三位分别是HPV16、59、58;≥2种HPV亚型混合感染在宫颈高级别和低级别病变组与正常对照组间差别有统计学意义(P<0.05)。结论 30~49岁年龄段HPV感染比例最高,宫颈上皮内瘤变比例随年龄及混合感染增高而增高;聊城市引起宫颈高级别上皮内瘤变的HPV亚型为HPV16、59、58。
Objective To investigate the HPV susceptibility of women of different ages and to analyze the distribution of different HPV subtypes in Liaocheng and the difference of cervical intraepithelial neoplasia. Methods From March 2014 to December 2015, 3 095 cases of cervical disease in our hospital were examined by HPV typing. Cervical cytology or colposcopy biopsy was performed on positive patients. The data were analyzed by SPSS 17.0 software. Results The number of HPV positive patients was 830, accounting for 26.82%. HPV infection was the most common in women aged 30-49 years, accounting for 31.20%. The top three most prevalent HPV subtypes in patients with high grade cervical lesions were HPV16, 59 and 58 . The mixed infection of ≥2 HPV subtypes had significant difference between the high grade and low grade cervical lesions and the normal control group (P <0.05). Conclusions The proportion of HPV infection in the age group of 30-49 years is the highest, while the proportion of cervical intraepithelial neoplasia is increasing with age and infection. HPV type HPV16,59,58 in high grade intraepithelial neoplasia in Liaocheng City.