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磷酸喹哌原系抗疟药,上海医药工业研究院等单位所作的动物实验证明对矽肺有防治效果,我所于1974年治疗单纯矽肺患者24例,其中矽肺Ⅰ、Ⅱ期各12例,病变多系进展快速者.用药剂量每次口服0.5克,每周一次,6个月为一疗程,每一个疗程间歇停药6个月,其中治疗6个疗程者4例,2个疗程以上者20例.四年来胸片随访结果:吸收好转和控制发展者22例(占91.6%),其中10例吸收好转者中,7例为矽肺Ⅱ期用药时间一年左右,继续用药时并不因疗程延长而继续增加疗效.有一例矽肺I期患者停药一年后病灶明显扩大,经继续服药病灶又吸收好转.
Phosphoric acid original antimalarial drug, Shanghai Institute of Pharmaceutical Industry and other units of animal experiments proved that prevention and treatment of silicosis have effect, I was treated in 1974, 24 cases of simple silicosis patients, including silicosis Ⅰ, Ⅱ 12 cases of each disease Multi-line rapid progression. The dosage of 0.5 grams per oral dose, once a week, 6 months for a course of treatment, intermittent withdrawal of each course of 6 months, of which 6 courses of treatment in 4 cases, 2 courses of more than 20 Cases of follow-up of chest radiography in four years: Twenty-two patients (91.6%) with improvement of absorption and control development, of which 10 were improved and 7 patients were treated with silicosis for about one year. The treatment was continued without medication Prolongation and continue to increase the efficacy of a case of silicosis I patients discontinued one year after the obvious enlargement of the lesion, and continue to take the lesion and absorption improved.